Phytosphingosine is a natural component belonging to the class of sphingolipids, polar lipids that are essential for the functioning of the cell membrane system that provides cell stability and contribute to the permeability and immunological barriers of the skin. Lipids are believed to form at least part of the microbial barrier.
It appears in the form of a white powder
What it is used for and where
Medical
Phytosphingosine has shown varying degrees of antimicrobial (1) and anti-inflammatory activity and has been shown to be effective in restoring the damaged skin barrier and controlling acne bacteria and Staphylococcus aureus. In addition, in in vitro studies, its anti-adherence and anti-biofilm properties preventing salivary biofilm formation (2) and antifungal activity against Candida albicans (3) have been confirmed.
Cosmetics
Phytosphingosine is a water-soluble lipid material, a moisturising agent developed in recent years with the ability to rapidly penetrate the skin and strengthen the stratum corneum by forming a mesh structure. It stimulates the differentiation of human epidermal keratinocytes and contributes to lipid nutrition for the synthesis of ceramides while also exerting discrete antimicrobial activity. Lipids are believed to form at least part of the microbial barrier and are synthesised in the epidermis. It produces an anti-desquamation and anti-ageing effect due to its properties of reconstituting the skin's natural barrier function.
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Typical commercial product characteristics Phytosphingosine
| Appearance | White powder |
| Boiling Point | 483.7±40.0°C at 760 mmHg |
| Melting Point | 102ºC |
| Flash Point | 246.4±27.3°C |
| Density | 1.0±0.1 g/cm3 |
| Vapor Pressure | 0.0±2.8 mmHg at 25°C |
| Refraction Index | 1.490 |
| Water | ≤2.0% |
| Residue on ignition | ≤0.5% |
| Heavy metals | ≤20 ppm |
| Total plate | ≤100cfu/g |
| Yeast and mold | ≤10cfu/g |
| Shelf life | 2 years |
- Molecular Formula C18H39NO3
- Molecular Weight 317.5
- Exact Mass 317.292999
- CAS 554-62-1
- UNII GIN46U9Q2Q
- EC Number 205-516-1
- DSSTox Substance ID DTXSID80203951
- IUPAC (2S,3S,4R)-2-aminooctadecane-1,3,4-triol
- InChl=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
- InChl Key AERBNCYCJBRYDG-KSZLIROESA-N
- SMILES CCCCCCCCCCCCCCC(C(C(CO)N)O)O
- MDL number
- PubChem Substance ID
- ChEBI 46961
Synonyms
- 4D-Hydroxysphinganine
- (2S,3S,4R)-2-Aminooctadecane-1,3,4-triol
