Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

Fallacara A, Busato L, Pozzoli M, Ghadiri M, Ong HX, Young PM, Manfredini S, Traini D. Combination of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate for the treatment of inflammatory lung diseases: An in vitro study. Eur J Pharm Sci. 2018 Jul 30;120:96-106. doi: 10.1016/j.ejps.2018.04.042.

Deng Q, Huang S, Wen J, Jiao Y, Su X, Shi G, Huang J. PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice. Stem Cell Res Ther. 2020 Apr 3;11(1):143. doi: 10.1186/s13287-020-01638-2.

Okajima LS, Martinez EF, Pinheiro IF, Fonseca Silva AS, Demasi APD. Effect of sodium ascorbyl phosphate on osteoblast viability and differentiation. J Periodontal Res. 2020 Oct;55(5):660-666. doi: 10.1111/jre.12752.

Spiclin P, Homar M, Zupancic-Valant A, Gasperlin M. Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm. 2003 Apr 30;256(1-2):65-73. doi: 10.1016/s0378-5173(03)00063-2.

Fallacara A, Marchetti F, Pozzoli M, Citernesi UR, Manfredini S, Vertuani AS. Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study. Pharmaceutics. 2018 Dec 1;10(4):254. doi: 10.3390/pharmaceutics10040254. 

Ruamrak C, Lourith N, Natakankitkul S. Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment. Int J Cosmet Sci. 2009 Feb;31(1):41-6. doi: 10.1111/j.1468-2494.2008.00479.x.

Foco A, Gasperlin M, Kristl J. Investigation of liposomes as carriers of sodium ascorbyl phosphate for cutaneous photoprotection. Int J Pharm. 2005 Mar 3;291(1-2):21-9. doi: 10.1016/j.ijpharm.2004.07.039. 

Fallacara A, Busato L, Pozzoli M, Ghadiri M, Ong HX, Young PM, Manfredini S, Traini D. Co-Spray-Dried Urea Cross-Linked Hyaluronic Acid and Sodium Ascorbyl Phosphate as Novel Inhalable Dry Powder Formulation. J Pharm Sci. 2019 Sep;108(9):2964-2971. doi: 10.1016/j.xphs.2019.04.015.

Segall AI, Moyano MA. Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. Int J Cosmet Sci. 2008 Dec;30(6):453-8. doi: 10.1111/j.1468-2494.2008.00473.x. 

Marra F, Levy JL, Santi P, Kalia YN. In vitro evaluation of the effect of electrotreatment on skin permeability. J Cosmet Dermatol. 2008 Jun;7(2):105-11. doi: 10.1111/j.1473-2165.2008.00372.x. 

Battino M, Ferreiro MS, Armeni T, Politi A, Bompadre S, Massoli A, Bullon P. In vitro antioxidant activities of antioxidant-enriched toothpastes. Free Radic Res. 2005 Mar;39(3):343-50. doi: 10.1080/10715760400023853.

Sicurezza

Elmore AR. Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics. Int J Toxicol. 2005;24 Suppl 2:51-111. doi: 10.1080/10915810590953851.