Poly(lactic acid-co-glycolic acid) or PGA, is a chemical compound , a copolymer composed of 2-hydroxypropanoyl and 2-hydroxyacetyl. It is a macromolecule of polyester copolymer and a macromolecule of polyester.
PLGA , due to its biocompatibility, biodegradability, a wide range of degradation rates and adjustable mechanical properties, has been widely applied in controlled drug release techniques. PLGA base has been used to construct a wide range of drug delivery systems for the treatment or diagnosis of various diseases and disorders.
In this study, biodegradable polydegradable (lactic-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) were tested as transient carriers for genetically engineered cells. To this end, we used human fibroblasts and examined the attachment and proliferation of non-transfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Bioresorbable PLGA scaffolds can be used as a vehicle for transiently transfected cell delivery and may pave the way for a variety of applications in gene therapy, tissue engineering, and regenerative medicine. Scaffolds with a condensed structure and smaller pore size could lead to improved cell- scaffold interaction and thus lead to higher yields of desired recombinant therapeutic proteins (1).
Commercially, there are several plates and screws for bone fracture fixation made with PLA, however, its long degradation time and lack of integration with bone structure, provides interest in research using polymers with faster degradation, such as PLGA, and together with bioceramics, in order to improve bioactivity in bone regeneration. The results of this study suggest changes in the thermal and mechanical properties of PLGA plates with bioceramic insertion and provide a better understanding of composites fabricated with PLGA and bioceramics (2).
In order to improve and enhance the performance of cosmetic products, nanospheresPLGA containing provitamin C have been used recently. The results show that the skin is improved under the ptofile of permeability and absorbability (3).
Poly(lactic acid-co-glycolic acid) studies
Molecular Formula : C5H8O5
Molecular Weight: 148.11 g/mol
CAS: 26780-50-7
Synonims:
- Acid Polyester, Glycolic-Lactic
- Glycolic Lactic Acid Polyester
- Dimethyldioxanedione Polymer with Dioxanedione Polymer
- Dioxanedione Polymer with Dimethyldioxanedione Polymer
- Poly(Lactide-Co-Glycolide)
- Poly(Lactide-Co-Glycoside)
- Polygalactin 910
- Glycolic-Lactic Acid Polyester
- Poly(Glycolide Lactide)Copolymer
- Polyester, Glycolic-Lactic Acid
