Lorazepam è un composto chimico, una benzodiazepina che ha proprietà antiansiolitiche, anticonvulsive e sedative e che può essere assunto solo se prescritto da un medico.

Assumere solo sotto controllo medico

Come tutti i farmaci può causare effetti collaterali. Consultare sempre il medico.

Formula molecolare: C₁₅H₁₀Cl₂N₂O₂

Peso molecolare: 321.2 g/mol

CAS: 846-49-1

EC Number: 212-687-6

DSSTox Substance ID: DTXSID7023225

Sinonimi: 

• Tavor
• Ativan
• Delormetazepam
• Temesta
• Anxiedin
• ecc

Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

Elliott HW. Metabolism of lorazepam. Br J Anaesth. 1976 Oct;48(10):1017-23. doi: 10.1093/bja/48.10.1017.

Greenblatt DJ. Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet. 1981 Mar-Apr;6(2):89-105. doi: 10.2165/00003088-198106020-00001.

Clarkson JE, Gordon AM, Logan BK. Lorazepam and driving impairment. J Anal Toxicol. 2004 Sep;28(6):475-80. doi: 10.1093/jat/28.6.475.

Ross M. Lorazepam-associated drug dependence. J R Coll Gen Pract. 1986 Feb;36(283):86.

Giersch A, Boucart M, Elliott M, Vidailhet P. Atypical behavioural effects of lorazepam: clues to the design of novel therapies? Pharmacol Ther. 2010 Apr;126(1):94-108. doi: 10.1016/j.pharmthera.2010.01.004.

Ameer B, Greenblatt DJ. Lorazepam: a review of its clinical pharmacological properties and therapeutic uses. Drugs. 1981 Mar;21(3):162-200. doi: 10.2165/00003495-198121030-00001.

Ativan (Lorazepam). J Addict Nurs. 2012 May;23(2):141-2. doi: 10.3109/10884602.2012.669122. 

Dundee JW, McGowan WA, Lilburn JK, McKay AC, Hegarty JE. Comparison of the actions of diazepam and lorazepam. Br J Anaesth. 1979 May;51(5):439-46. doi: 10.1093/bja/51.5.439.

Ettinger U, Meyhöfer I, Mehta MA, Kumari V, Corr PJ, Williams SC, Perkins AM. Effects of lorazepam on saccadic eye movements: the role of sex, task characteristics and baseline traits. J Psychopharmacol. 2018 Jun;32(6):678-690. doi: 10.1177/0269881118772450.

Dahal A, Neupane R, Boddu SH, Renukuntla J, Khupse R, Dudley R. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. Int J Pharm Compd. 2020 Mar-Apr;24(2):168-175.

Chennou F, Bonneau-Fortin A, Portolese O, Belmesk L, Jean-Pierre M, Côté G, Dirks MH, Jantchou P. Oral Lorazepam is not Superior to Placebo for Lowering Stress in Children Before Digestive Endoscopy: A Double-Blind, Randomized, Controlled Trial. Paediatr Drugs. 2019 Oct;21(5):379-387. doi: 10.1007/s40272-019-00351-9. 

Wu W, Zhang L, Xue R. Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis. J Clin Neurosci. 2016 Jul;29:133-8. doi: 10.1016/j.jocn.2015.10.038.