Review

AColumn (9287 pt) • 2020-Apr-14 09:36

Hederagenin is a pentacyclic triterpenoid, monocarboxylic dihydroxy acid and sapogenin. It comes from an oleanolic acid.

It is found in ivy (Hedera helix L.) and many plants (Lonicera fulvotomentosa, Paeonia Ostii, Akebiae Caulis, Momordica cochinchinensis, Crossopteryx Febrifuga, Caulophyllum robustum, Medicago truncatula, Chenopodium Quinoa, Blighia unijugata, Achyranthes bidentate, Cussonia bancoensis, Clematidis Radix).

The scientific literature attributes it a wide range of properties such as anti-inflammatory, antidepressant, hepatoprotective (1).

Hederagenin inhibits proliferation and facilitates apoptosis of cervical cancer cells by inhibition of the STAT3 signaling pathway (1).

Hederagenin in-depth studies

Molecular Formula: C₃₀H₄₈O₄

Molecular Weight: 472.7 g/mol

CAS: 465-99-6

UNII RQF57J8212

EC Number: 207-369-9

MDL number MFCD00017385

NACRES NA.25

Sinonimi:

3,23-Dihydroxyolean-12-en-28-acid
Astrantiagenin E
Caulosapogenin
Hederagenic acid
Hederagenol

References________________________________________________________________________

(1) Ma XL, Li WX, Wang D, Lu FP, Dai ZB, Zhang XL. Biosynthesis Analysis of Hederagenin Pathway and Its Construction in Yeast Cells Zhongguo Zhong Yao Za Zhi. 2018;43(9):1844–1850. doi:10.19540/j.cnki.cjcmm.20180307.008

(2) Fang L, Liu M, Cai L. Hederagenin Inhibits Proliferation and Promotes Apoptosis of Cervical Cancer CaSki Cells by Blocking STAT3 Pathway. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2019;35(2):140–145.

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