Review

AColumn (9287 pt) • 2019-Nov-17 10:41

Atorvastatin, a member of the statin family and one of the statin class inhibitors, is a lipidic agent that lowers levels of 3-hydroxy-3-methylgutaryl-CoA (HMG-CoA) reductase, so as to reduce elevated level of low density lipoproteins (LDL) cholesterol and cardiovascular risk.

In addition to its anti-cholesterol properties, atorvastatin has been shown to suppress the proliferation of cancer cells and induce apoptosis (1) and also playing a role in immunosuppression, fighting inflammation (there is a close association between inflammation and tumor), preventing dementia.

However, it has a problem of scarce gastric solubility and low total bioavailability together with higher pre-system clearance.

It has also demonstrated an antifungal ability against Candida albicans in vivo and in vitro (2).

in this study atorvastatin demonstrated positive effects on erectile function after radical prostatectomy surgery (3).

It also limited the influenza virus to generate lipid droplets and greatly suppresses virus replication (4).

Like all drugs it can cause side effects. Always consult your doctor.

Atorvastatin studies

Molecular Formula: C₃₃H₃₅FN₂O₅

Molecular Weight: 1209.4 g/mol

CAS: 134523-00-5 110862-48-1

UNII: A0JWA85V8F

Sinonimi:

Cardyl
Tozalip
Liprimar
atrovastin
Lipotropic
Vastina
Xanator
Zurinel
Atogal
Atorin
Lowden
Sincol
Ator
Atofast
Atorcor
Atorlip
Atorpic
Faboxim
Lipilou
Lipinon
Torvacard
Tulip
Xavator
Xarator
Sotis
Lipitor
Torvast
(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, (R-(R*,R*))-
(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid
(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-, (betaR,deltaR)-

References___________________________________________________

(1) Proteome and phosphoproteome reveal mechanisms of action of atorvastatin against esophageal squamous cell carcinoma. Yuan Q, Dong CD, Ge Y, Chen X, Li Z, Li X, Lu Q, Peng F, Wu X, Zhao J, Liu K. Aging (Albany NY). 2019 Nov 7;11. doi: 10.18632/aging.102402.

(2) Assessment of the in vitro and in vivo activity of atorvastatin against Candida albicans. Ajdidi A, Sheehan G, Abu Elteen K, Kavanagh K. J Med Microbiol. 2019 Oct;68(10):1497-1506. doi: 10.1099/jmm.0.001065.

(3) Effects of Preoperative Atorvastatin Treatment On Erectile Function After Radical Prostatectomy: Results From a Subgroup of ESTO1, a Randomized, Double-Blind, Placebo-Controlled Study. Siltari A, Riikonen J, Fode M, Murtola TJ. J Sex Med. 2019 Oct;16(10):1597-1605. doi: 10.1016/j.jsxm.2019.07.001

(4) Atorvastatin restricts the ability of influenza virus to generate lipid droplets and severely suppresses the replication of the virus. Episcopio D, Aminov S, Benjamin S, Germain G, Datan E, Landazuri J, Lockshin RA, Zakeri Z. FASEB J. 2019 Aug;33(8):9516-9525. doi: 10.1096/fj.201900428RR.

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