White horehound ( Marrubium vulgare )

White horehound ( Marrubium vulgare , family Lamiaceae ) is a perennial herb traditionally used in herbal practice and, to a more limited extent, in flavoring food preparations. It is known for its bitter and balsamic sensory profile, mainly linked to constituents of the aerial parts.

Its main application interest concerns phytotherapy and over-the-counter products based on herbal extracts; in cosmetics it may appear as an extract for functional purposes (e.g., support for oily/blemish-prone skin or “comfort” formulations), depending on standardization and the supplier’s technical documentation.

Table 1. Identification data and specifications (indicative)

Plant characteristics

The plant shows erect or ascending stems, often tomentose, with opposite leaves typical of Lamiaceae. Inflorescences are arranged in verticillasters; the surface may feel velvety due to hairs. From a sensory standpoint, the dried herb is characterized by a pronounced bitter taste and a herbaceous-resinous aroma.

Cultivation

It prefers sunny exposure and well-drained soils, including poor or calcareous soils. It is generally hardy, with good drought tolerance once established. Harvest for herbal use often focuses on flowering tops, selecting periods when the plant shows the best balance between yield and active-constituent content (variable with climate and phenology).

Table 2. Key constituents and functional profile (indicative)

Main uses

Food: limited use as a bittering or flavoring plant in traditional preparations; the most practical food-related use is as an infusion or decoction, considering the pronounced taste.

Cosmetics: Marrubium vulgare extracts may be included in formulas for oily/blemish-prone skin or products aiming for a sense of balance and “fresh feel,” often in synergy with humectants and soothing agents; actual functionality depends on assay, solvent, and dosage.

INCI functions: skin conditioning agent; astringent (if supported by the derivative profile); antioxidant (if supported by phenolic constituents).

Medicine / pharmaceutical: in phytotherapy it is traditionally associated with uses as an expectorant and as support in respiratory tract discomfort, as well as a bitter-digestive role. Any health-related use requires attention to posology, standardization, and safety warnings.

Industrial use: possible use of standardized extracts as functional ingredients in herbal products, supplements, or cosmetics; for technical non-food/non-cosmetic applications, interest is generally secondary compared to other botanical matrices.

Environmental and safety considerations

Environmental impact: a species that can be cultivated with moderate inputs; supply-chain quality depends on cultivation/harvesting practices that preserve the resource and reduce contamination (dust, metals, residues). For extracts intended for cosmetics or supplements, origin traceability and contaminant control are important.

Safety: it is not commonly considered a “high-risk” plant in traditional use, but tolerability depends on dose, individual sensitivity, and form of use. Practical contraindications may include gastric irritation in individuals sensitive to bitter principles, caution in pregnancy/breastfeeding for uncontrolled internal use, and caution when combined with concomitant therapies without professional supervision. Regarding allergenicity, it is not typically classified as a priority food allergen, but it may cause reactions in individuals predisposed to Lamiaceae plants or extract constituents; in cosmetics, compatibility for reactive skin should be assessed based on supplier documentation.

Studies

In this study, the results show that a methanolic extract of Marrubiin protects the myocardium against acute myocardial infarction induced by isoproterenol and suggests that the effects may be related to antioxidant activity (1).

Methanol extract and Marrubin diterpene obtained from Marrubian leaves have demonstrated gastroprotective properties this effect can be partly attributed to isolated diterpene (2).

In Algeria, this plant is traditionally used against diabetes and, within it have been identified flavonoids, chlorogenic acid (3).

It also exerts an analgesic action, related to the presence of steroids and terpenes detected by TLC analysis (4) and an antispasmodic activity (5).

White horehound studies

References___________________________________________

(1) Yousefi K, Soraya H, Fathiazad F, Khorrami A, Hamedeyazdan S, Maleki-Dizaji N. et al. Cardioprotective effect of methanolic extract of Marrubium vulgare L. On isoproterenol-induced acute myocardial infarction in rats. Indian J Exp Biol. 2013;51(8):653–60

Abstract. Isoproterenol injection (100 mg/kg; sc) produced changes in ECG pattern including ST-segment elevation and suppressed R-amplitude. The methanolic extract of M. vulgare at doses of 10, 20, and 40 mg/kg significantly amended the ECG changes. A severe myocardial necrosis and edematous along with a sharp reduction in the arterial blood pressure, left ventricular contractility (LVdP/dt(max or min)), but a marked increase in the left ventricular end-diastolic pressure (LVEDP) were seen in the isoproterenol group. All parameters were significantly improved by the extract treatment. The extract (10 mg/kg) strongly increased LVdP/dt(max). Similarly, treatment with 40 mg/kg of M. vulgare lowered the elevated LVEDP and the heart to body weight ratio. In addition to in vitro antioxidant activity, the extract suppressed markedly the elevation of malondialdehyde levels both in serum and in myocardium. The results demonstrate that M. vulgare protects myocardium against isoproterenol-induced acute myocardial infarction and suggest that the effects could be related to antioxidant activities.

(2) de Oliveira AP, Santin JR, Lemos M, Klein Júnior LC, Couto AG, da Silva Bittencourt CM. et al. Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae) J Pharm Pharmacol. 2011;63(9):1230–7. doi: 10.1111/j.2042-7158.2011.01321.x

(3) Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G. Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion. Fitoterapia. 2012;83(2):286–92. doi: 10.1016/j.fitote.2011.11.005

(4) de Souza MM, de Jesus RA, Cechinel-Filho V, Schlemper V. Analgesic profile of hydroalcoholic extract obtained from Marrubium vulgare. Phytomedicine. 1998;5(2):103–7. doi: 10.1016/S0944-7113(98)80005-6

(5) Schlemper V, Ribas A, Nicolau M, Cechinel Filho V. Antispasmodic effects of hydroalcoholic extract of Marrubium vulgare on isolated tissues. Phytomedicine. 1996;3(2):211–6. doi: 10.1016/S0944-7113(96)80038-9