![]() | "Descrizione" about LevoRag Emulgel by Al222 (21080 pt) | 2024-May-04 16:25 | ![]() |
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Review LevoRag Emulgel
Ingredients
What it is used for
Supplements and medicines are examined and evaluated solely from the point of view of their chemical composition, based on the relevant scientific studies. No medical opinion is expressed on curative functions. If a medicinal or prescription substance is involved, the overall judgement must be made by the treating physician.
Let us examine the most significant ingredients in order of quantity as indicated on the label. I provide a brief summary for reasons of space. For the full text, studies and bibliography, I highly recommend clicking on the ingredient In the description page and, if you want to go deeper, it is perhaps a little complex reading because these are scientific studies, but it clarifies the ingredient/health relationship.
Considerations
The 3.5 ml single-dose tubes are very practical and easy to use; just insert the straw and press. Typically, the product does not come out completely, but the amount that usually remains is very small. The healing functionality is good, and the wound tends to heal within 5 to 6 days.
I used this product for 5 days, but unfortunately I had to discontinue use because I experienced a pulsating irritation in my eyes, which I believe was due to Phenoxyethanol. My doctor replaced this product with Pfizer's Preparation H suppositories, which significantly alleviated the symptoms within 3 to 4 days.
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![]() | "Review Aulin® " about Aulin® 100 mg Review Consensus 20 by Al222 (21080 pt) | 2023-Feb-17 10:16 | ![]() |
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Review Aulin® 100 mg
Indications: Painkiller
Supplements and medicines are examined and evaluated here solely from the point of view of their chemical composition, based on relevant scientific studies. No medical opinion is expressed on curative functions. The opinion must be expressed by the treating physician.
Ingredients:
Let us look at the most significant ingredients in order of quantity as indicated on the label. For reasons of space, here is a brief summary. For the full text, studies and bibliography, just click on the ingredient and, if you want to go deeper, it is perhaps a little complex reading because it deals with scientific studies, but it clarifies the ingredient/health relationship.
There are three versions of Aulin® : tablets, sachets and suppositories. I have only tried two: tablets and sachets.
Active ingredient: Nimesulide
Non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, launched on the market in 1985 in Italy and marketed in more than 50 countries worldwide with relatively low risk of gastrointestinal side effects. Not available in the United States.
A brief history
Nimesulide was reported to be hepatotoxic in 1997 and its use was restricted or banned in 2002 first in Finland and then in Spain due to the high frequency of associated hepatotoxicity. However, several studies have downgraded the problem and the European Medicines Agency, after an extensive study, recognised its analgesic efficacy in
taking into account the risk/benefit ratio, only recommended a maximum daily dose for the 100mg dose. Stricter restrictions apply to the 200mg dose.
An important study from 2010 clarifies the risk/benefit ratio comprehensively: "Results suggest that implementation of regulatory actions regarding nimesulide may have prevented 79 admissions for liver damage, but increased admissions for UGIB by 859 cases."
Nimesulide as a preferential inhibitor of cyclooxygenase-2 could play a potential therapeutic role in the management of patients with cerebral ischaemia and, together with silver complexes, a potential safe agent for the topical treatment of skin cancer in humans.
Antidiabetic activity of Nimesulide has also been demonstrated.
However, recently, a study by the Universities of Brazil, Spain and Argentina has re-proposed, this time negatively, the risk/benefit ratio of Nimesulide. Frankly, from the consumer's point of view, it is difficult to make a choice since studies differ in their conclusions. The only solution is to ask your doctor for advice.
Tablet excipients:
Docusato sodico Emulsifier in tablets and pharmaceutical preparations. It is also an effective remedy against constipation and in particular as a stool softener. although Psyllium has been shown to be more effective.
Idrossipropilcellulosa is used for its biocompatibility as a drug carrier, emulsion stabiliser, binder, thickener. In particular, as hydroxypropylcellulose exhibits both organic and water solubility, it is suitable for solvent methods of drug delivery to produce solid dispersions. At low viscosity, hydroxypropylcellulose is an excellent pharmaceutical excipient. Due to its bioadhesive and hydrophilic properties it can be used mainly in topical and oral pharmaceutical formulations.
Lattosio monoidrato filling binder and compression aid in pharmaceutical mixtures.
Carbossimetalamido sodico is a plant polysaccharide extracted mainly from maize. It acts as a superdisintegrator for all solid oral dosage forms. It has a capacity to swell to 280 - 320 times its original granule volume. It is an excipient especially used for wet or dry granulation and direct compression and can be incorporated in intra- or extra-granular mode. or both. It generally has a potato starch base. It is produced in two types: Type A with low viscosity and low residual solvent and Type B which is particularly suitable for strongly acidic drug formulations to maintain stability and resist acidic pH.
E460 Cellulosa microcristallina, thickener and stabiliser.
E572 Magnesio stearato A classic excipient for solid oral dosage forms. It is used as an essential lubricant in production for dissolution, disintegration and hardness of the tablet, or in this case, the powder.
Excipients of sachets:
Cetomacrogol 1000 Solubiliser for poorly soluble drugs.
Acido citrico is used in pharmacological formulations such as 'gummy' formulations and to suppress the bitter taste of certain ingredients. This gives it the effect of a 'flavour enhancer'.
Amido di mais has the task of facilitating the disintegration of the tablet or powder.
Aroma arancio is a generic term for a fragrance. Flavours may be natural products, but most are of chemical origin. No manufacturer declares which chemical compound is behind it.
Conclusions
Aulin® is a well-known drug and, in my experience, I much prefer the tablet version to the sachet version. The reason for this is that the two chemical compounds 'Cetomacrogol 1000' and 'Aroma' are included in the formula for the sachets, which I prefer to avoid, as can be seen from the descriptions and scientific studies cited. Nothing serious, of course, but I think the tablet version is much better.
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![]() | "Descrizione" about URIAGE Bariéderm-CICA 40g Review Consensus 10 by Al222 (21080 pt) | 2022-Jul-12 12:04 | ![]() |
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REVIEW URIAGE Bariéderm-CICA 40g
Ingredients:
Indications:
Reinforces the skin barrier.
Let us examine the most significant ingredients in order of quantity as indicated on the label. Here is a brief summary for the sake of space. For the full text, studies and bibliography, just click on the ingredient and, if you want to go deeper, it's perhaps a little complex reading because it's scientific studies, but it clarifies the ingredient/health relationship.
Paraffinum liquidum is the name of paraffin in liquid form, a highly refined mineral oil used as a softener in skin care formulations.
Hydrogenated polydecene, a natural product obtained chemically, i.e. synthesised through a hydrogenation process. Polydecene is a branched aliphatic solvent. Hydrocarbon surfactant with high surface tension acting as an emollient.
Microcrystalline wax, a purified product based on saturated hydrocarbons, used as an adhesive and emulsifying stabiliser often replacing paraffin wax as it has shown better elastic characteristics and less sticky adhesion.
Dimethicone It is a non-neurotoxic topical agent with an emulsifying function effective in the treatment of actinic keratoses on the face.
Panthenol, derived directly from vitamin B5 or pantothenic acid, it has favourable and lasting effects on barrier function and repair, as well as on skin hydration without adversely affecting bacterial viability in the skin microflora.
Avocado oil, Protective antioxidant agent that counteracts dehydration.
Glycerin Trivalent alcohol, hygroscopic. Glycerol is the trade name when the percentage of glycerol exceeds 95%, but the names are mostly used to identify the same product. Moisturising, lubricating, it is included in the formula with the aim of moisturising and softening the skin, preserving it from ageing or roughness.
Triacontanyl PVP. Viscosity control agent and film-forming agent, i.e. able to create a protective anti-wear and waterproof film.
Butyrospermum Parkii Butter. is a butter obtained from the Shea tree (Vitellaria paradoxa) native to Africa, and has been used to treat mild to moderate atopic dermatitis and as a decongestant.
Dipentaerythrityl tetrahydroxystearate/tetraisostearate Skin conditioning agent, hydrophobic, has the capacity to retain water, thanks to the presence of hydroxyl groups in the molecule. It is generally used as a substitute for lanolin.
Brassica campestris (Rapeseed) sterols. Plant sterols generally promote the regeneration of skin cells. In this formula, the sterols are from rapeseed.
Squalane is a bioactive substance, a saturated oil derivative of squalene that is found in shark liver oil, vegetable oils and human sebum. It is a very stable emollient and moisturising agent that has a remarkable ability to penetrate and impart flexibility to human skin and increase the absorption of other active substances.
Tocopheryl acetate. Powerful antioxidant, basically a synthesised vitamin E with proven efficacy in skin regeneration.
Ethylene/propylene copolymer, linear copolymer acting as a mild skin abrasive.
Polyquaternium-61, quaternary ammonium salt conditioning agent, humectant and antistatic, with high charge density and good stability.
Tocopherol Vitamin E antioxidant and skin conditioning agent.
BHT Butyl hydroxytoluol derived from phenol is an antioxidant.
Conclusions
Excellent product for the care of damaged skin. Tried personally.
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![]() | "Descrizione" about Vytorin 10MG+10MG 30CPR Review Consensus 9 by Al222 (21080 pt) | 2022-Nov-30 11:26 | ![]() |
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Review VYTORIN 30CPR 10mg+10mg
Instructions
my translation from the package insert :
"VYTORIN contains the active ingredients ezetimibe and simvastatin."
VYTORIN is a medicine that is used to decrease levels of total cholesterol, "bad" cholesterol (LDL-cholesterol), and fatty substances called triglycerides in the blood. In addition, VYTORIN increases levels of "good" cholesterol (HDL cholesterol). VYTORIN works in two ways to lower cholesterol. The active ingredient ezetimibe reduces cholesterol absorbed in the digestive tract. The active ingredient simvastatin which belongs to the class of "statins" inhibits the production of cholesterol synthesized by the body. Cholesterol is one of several fatty substances found in the bloodstream. Total cholesterol is composed mainly of LDL cholesterol and HDL cholesterol."
Supplements and medicines are examined and evaluated solely from the point of view of their chemical composition, based on relevant scientific studies. No medical opinion is expressed on curative functions. If it is a prescription medicine, the judgement must be made by the treating physician.
Let us examine the most significant ingredients in order of quantity as indicated on the label. I provide a brief summary for reasons of space. For the full text, studies and bibliography, just click on the ingredient and, if you want to go deeper, it is perhaps a little complex reading because these are scientific studies, but it clarifies the ingredient/health relationship.
Ingredients
Active ingredients
Each tablet contains 10 mg of ezetimibe and 10 mg of simvastatin.
Excipients and fim coating:
butilidrossianisolo, acido citrico monoidrato, croscarmellosa sodica, ipromellosa, lattosio monoidrato, magnesio stearato, cellulosa microcristallina, propile gallato.
The tablets do not have a dividing line so they should not be divided.
Let's review the ingredients according to the quantities in the order listed on the label.
Ezetimibe. It is a cholesterol absorption inhibitor with lipid-lowering activity and is a derivative of azetidinone.Ezetimibe significantly reduces the risk of myocardial infarction and stroke.
Simvastatina. A hypolipidemic drug, that is, one with activity in reducing levels of harmful LDL cholesterol and anti-inflammatory. Reductase inhibitor. Statin. Statins are taking on a key role in the prevention and treatment of heart disease, specifically hypercholesterolemia, and possess immunomodulatory properties.
Butilidrossianisolo. It is a widely used antioxidant additive in the cosmetic industry. and food industry, especially in cereals, chewing gum, potato chips, vegetable oils, also in pharmaceuticals, rubber and petroleum products. The Panel on Food Additives and Nutrient Sources (EFSA, 2012 ) suggested for the acceptable daily intake level (ADI) 1 mg/kg body weight/day for BHA.
Acido citrico. It is a tricarboxylic acid and is obtained from lemon juice and other fruits, beet juice and other vegetables and is used by the pharmaceutical industry as an excipient in pharmaceutical products with functions of anticoagulant, antioxidant, preservative.
Croscarmellosa sodica (E468, Sodium CNC) è un composto chimico emulsionante formato da cellulosa grezza trattata con composti di sodio. Serve per migliorare e accelerare il rilascio del farmaco nell'intestino.
Ipromellosa (HMPC) is a chemical compound usually used in the presence of cellulose as an emulsifier, stabilizer, suspending agent or thickener in food.
Lattosio monoidrato Is a disaccharide sugar that is extracted from milk. Industrially it is a chemical compound in the form of a white powder commonly used as a binding excipient, filling binder and compression aid in pharmaceutical mixtures
Magnesio stearato. In the pharmaceutical industry, it is an excipient for oral solid dosage forms.It is used as an essential lubricant in tablet manufacture, dissolution, disintegration and hardness.
Cellulosa microcristallina. In the pharmaceutical industry, it is used as a coating for medicinal tablets.
Propile gallato is a chemical compound, propyl ester of gallic acid, is one of the synthetic phenolic antioxidants (ZPS) that are added to fats and fried foods as food additives to minimize oxidative rancidity of oils and fats. Labeled with the number E310 in the list of food additives as an antioxidant and as such it performs its function in these tablets.
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![]() | "Descrizione" about Sertralina Eurogenerici® 50 mg Review Consensus 8 by Al222 (21080 pt) | 2022-Mar-08 09:23 | ![]() |
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Frankly, the presence of a decidedly "unhealthy" ingredient that could therefore cause health problems in a medicine is surprising. The only explanation maybe is the dated formulation and not updated with recent studies. On the other hand, unfortunately, until the ingredient (Titanium Dioxide is banned in some European countries but not yet in Italy and yet it is present in many medicines) will not be banned also in Italy, there is nothing to do. Pharmaceutical companies answer: excipient approved by the competent Authority.
18-4-2021 Today I wrote these comments to the EMA (European Medicines Agency) and to Europe Direct Contact Center asking for a written response.
4-6-2021 Response:
Regarding titanium dioxide, the European Food Safety Authority published its opinion on May 6, 2021 and concluded that, based on all available evidence, a concern for genotoxicity cannot be ruled out, and given the many uncertainties, E 171 can no longer be considered safe when used as a food additive. As mentioned in a tweet on the same day, following EFSA's new scientific opinion on the food additive E171, we will propose to ban its use in the EU. https://twitter.com/food_eu/status/1390347410476523521
Regarding medicinal products, the Commission has asked the European Medicines Agency to assess the effect on the use of TiO2 in medicinal products and the feasibility of alternatives to replace TiO2, if possible, without impact on the quality, safety and efficacy of medicinal products. A decision will be made by the Commission based on the analysis provided by the Agency."
All we can do is hope and wait (how much?).
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